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Enhancement of virus infectivity Oxidative stress exacerbates the pathogenesis of coxsackievirus B3 (CVB3) infection in mice, and the change in virulence is attributed to changes in the viral genome and in the immune functions of the oxidatively stressed mice ( Perinatal cytomegalovirus (CMV) infection has been suggested to be a possible cause or trigger of BA, in that CMV infection initiates damage to the bile duct, which is then followed by autoimmune responses targeting the bile duct