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While the FDA is expected to face lawsuits, Richardson said she and other public health leaders hope it will act soon

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A recent network meta-analysis assessing oral health effects across non-combustible nicotine products did not identify any eligible randomized controlled trials on nicotine pouches, and the relatively short follow up period of the included studies did not allow for evaluation of their potential impact on oral carcinogenesis (60, 61)

In reality, the direct exposure of certain areas of the mouth to tobacco increases the risk of severe health complications, which are not limited to the oral cavity but also extend to the esophagus, colon, pancreas, and bladder, due to the absorption and ingestion of tobacco juices, said Dr Jinan Mohammed Suleiman, a family physician at PHCC