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Dose-escalation decisions in both phases are evaluated by a Safety Review Committee (SRC) , which assesses clinical, pharmacokinetic and safety data according to predefined stopping rules established in the study protocol
Multiple anatomical and physiologic factors reduce oxygen diffusion into wound beds resulting in delayed healing 1-3
You can also speak with your healthcare provider about potential outpatient treatment, especially if you are a high-risk individual. If symptoms get worse, call an emergency department, urgent care, primary care provider or your local health department ahead of time to receive guidance on coming in for testing and treatment
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