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Since this study, several other publications highlighted the potential interest of Fisetin to treat different diseases related to senescence cells accumulation such as kidney fibrosis 20 or muscular dystrophy 21

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284,285,286 The SARS-CoV-2 virus replicates rapidly in infected organoids to induce proinflammatory cytokine/chemokine production, local hepatocyte and bile duct cell damage, and consequent bile acid accumulation

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