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Figure 5 4.4 Direct TAM cancer cell ferroptosis interactions: a mechanistic narrative Tumor-associated macrophages (TAMs) orchestrate ferroptotic sensitivity in cancer cells through a set of tightly interlinked metabolic and immunological interactions ( Bidirectional signaling further reinforces this crosstalk: tumor-cellderived lactate, HMGB1, prostaglandins, and oxidized lipids polarize macrophages toward either ferroptosis-promoting (M1-like) or ferroptosis-restraining (M2-like) states

The sensitivity of GRs is primarily modulated by FK506 binding protein 5, which is linked to several mental illnesses and stress-related conditions, including severe depression, bipolar disorder, childhood trauma, post-traumatic stress disorder, as well as violent and suicidal behaviors (Menke, 2019)

Stale COAs may not reflect current batches

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