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While previous research has examined the effects of genes related to dopamine, a chemical in the brain associated with reinforcing the effects of nicotine, this study provides the first evidence that genes that alter dopamine function may influence smoking cessation and relapse during treatment, said lead author Caryn Lerman, Ph.D., associate director for Cancer Control and Population Science at the Abramson Cancer Center of the University of Pennsylvania and professor in Penns School of Medicine and the Annenberg Public Policy Center