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In macrophage lineage cells, second signal urate crystal uptake is followed by phagolysosome destabilization with intracellular protease release, reactive oxygen species generation and decreased intracellular potassium, via cell swelling and potassium efflux

207-OR: Myostatin inhibition synergizes with GLP-1R agonism to accelerate weight loss in male, obese nonhuman primates