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Key outcomes: At the 10-year mark, patients who underwent metabolic surgery had significantly better outcomes: 32% lower risk of death 35% lower risk of major adverse cardiovascular events (MACE) , including heart attack, heart failure, or stroke 47% lower risk of chronic kidney disease (CKD) 54% lower risk of diabetes-related retinopathy (eye damage) The 10-year cumulative incidence of all-cause mortality was 9.0% (95% CI 6.810.8%) in the metabolic surgery group, compared with 12.4% (95% CI 9.915.2%) in the GLP-1RA group (adjusted hazard ratio 0.68, 95% CI 0.480.96

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The antibiotic nitrofurantoin (NFT) was identified to stimulate de novo synthesis of glutathione in the human hepatoma cell line, HepG2, and in primary human hepatocytes

Advise patients of the characteristic symptoms of heart failure and to immediately report such symptoms