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Using these datasets, an overlap was found in gene expression related to oxidative stress, xenobiotic metabolism, AhR and Nrf2 pathways, as shown by a positive association between the in-vitro study and the former two in-vivo smoker studies, and a negative association with the in-vivo smoking cessation study (Additional file 2: Table S3)

Primary drivers include WHO-validated harm-reduction evidence (95% less harmful per Public Health England), UK NHS smoking cessation endorsement, flavor innovation across 6 categories, and online retail channel expansion at ~9.1% CAGR

The retailer has the opportunity to opt-in or opt-out during certain periods or run the program all year round

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