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It is also known that oral contraceptives may lower pyridoxine levels in some individuals, which could be considered a drug-nutrient interaction of clinical relevance

In patients with an equivocal or clinically puzzling serum vitamin B12 result, MMA can be useful

Vitamin B12 deficiency can be caused by several factors, including: Inadequate dietary intake: Since vitamin B12 is naturally found in animal-based foods, strict vegetarians and vegans who do not consume fortified foods or supplements are at risk of developing a deficiency

B12 injections: Intramuscular injections of vitamin B12 is one of the most common forms of administration, but it must be done by a medical professional (Shipton, 2015)