9,10 The mechanism of the relationship is poorly understood, with hypotheses including that a drop in blood sugar can lead to a rise in VEGF expression 11,12 and that systemic glycemic changes can correspond with glucose concentration in the vitreous, and in turn lead to retinal injury
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Patients seeking GLP-1 therapy should rely on FDA-approved medications with established efficacy profiles, including landmark trials like STEP (semaglutide) demonstrating approximately 15% body weight reduction and SCALE (liraglutide) showing 5-8% weight reduction, along with improved glycemic control in patients with diabetes
Smith explained that while many prescriptions are for diabetes, the same companies have rebranded products specifically for weight loss, contributing to the demand