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However, up to 40% of patients do not achieve satisfactory relief, prompting investigation of combination therapy, most commonly adding a second agent (e.g., duloxetine plus pregabalin), which can yield incremental pain reduction of 1020% but with increased risk of sedation, dizziness and drug interactions [64]

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N Engl J Med 2021;385:50315.ArticlePubMed 91

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If the picture supports a different peptide or a different intervention entirely, that is what we run

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