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Assessment of which components providing most benefit

These agents, including semaglutide and liraglutide, enhance insulin secretion in a glucose-dependent manner

Therefore, as the next step in their therapy, a long acting GLP-1 analogue (dulaglutide) was started at 0.75 mg a week and titrated up to 1.5 mg a week

Concurrently, TNF- and TGF-1 drive CSMC apoptosis and fibroblast-like phenotypic transformation, resulting in cavernous fibrosis and reduced tissue distensibility, while inflammatory cytokines and excessive ROS impair penile nerve integrity and neurotransmitter release, exacerbating neurogenic ED in animal studies (205)