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According to NICE guideline NG28, GLP-1 receptor agonists may be considered when triple therapy with metformin and two other oral drugs is not effective, not tolerated or contraindicated, and typically for patients with a BMI 35 kg/m (adjusted for ethnicity) or those for whom weight loss would benefit other significant obesity-related comorbidities

To reconstitute, slowly inject the appropriate volume of bacteriostatic water into the vial, directing the stream against the glass wall rather than directly onto the powder

If you're weighing that question, this comparison of Lexapro vs Wellbutrin can help frame why one antidepressant may feel more sedating while another feels more activating

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