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An inherited condition called alpha-1 antitrypsin (AAT) deficiency enlarges the peril of early-onset emphysema, particularly among smokers, as highlighted in Yale Medicines Fact Sheets. Heart disease : As nicotine raises blood pressure and increases heart rate it contributes to a higher risk of heart attacks, stroke, and other cardiovascular problems

Smoke contains thousands of chemicals, including tar, nicotine, and carbon monoxide

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The authors noted that despite the lack of understanding of the long-term health impact of e-cigarette use, the contribution of current e-cigarette use to rising healthcare spending is significant and should not be overlooked. This excess spending is particularly relevant for employers, who cover over half of Americans through employer-sponsored health insurance