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More than 80% of patients have mutations in one of the following genes (1): Endoglin (ENG) gene, which encodes a receptor for transforming growth factor beta-1 (TGF-1) and transforming growth factor beta-3 ACVRL1 gene, which encodes the activin receptor-like kinase (ALK1) MADH4 gene, which encodes SMAD4, a protein active in the TGF beta signaling pathway HHT is a disorder in which some blood vessels do not develop properly

The agency is concerned that e-cigarettes can expose users to chemicals known to be toxic to humans, increase nicotine addiction among young people, and are sold without any age restriction in flavors that may appeal to young people

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