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( F ) Luminescence recorded from HeLa cells either expressing or not expressing APEX2, pre-treated for 20 min with luminol and substrate (HPI) (250 M each), and then exposed to H 2 O 2 (50 M)

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We show, using high-resolution cryo-EM, the binding of a benzene sulphonamide compound with a PV serotype 2 VLP, consistent with antiviral activity through over-stabilizing the interprotomer pocket, preventing the capsid rearrangements necessary for viral infection

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