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GLP-1 receptor agonists function by: Stimulating insulin release when blood sugar levels are high Reducing glucagon secretion, which helps lower blood sugar Slowing gastric emptying, leading to increased satiety Affecting appetite centers in the brain, reducing food intake While these mechanisms contribute to the drugs effectiveness, they may also play a role in potential side effects, including the rare but serious risk of NAION

Production simulations were conducted using a LFMiddle Langevin Integrator in a NPT ensemble (simulation parameters summarized in Extended Data Table 3) 77