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Prog Mol Biol Transl Sci

Intracellular replication of Staphylococcus aureus in mature phagolysosomes in macrophages precedes host cell death, and bacterial escape and dissemination

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Since skin steroidogenesis can be modulated by external factors and is locally restricted, there is a tremendous potential for novel topical therapeutic approaches targeting skin estrogen biosynthesis to achieve local estrogen healing benefits without off-target effects which are undesirable in both men and women, as explained in the following section