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Isotretinoin and Thalidomide Down-Regulate c-MYC Gene Expression and Modify Proteins Associated with Cancer in Hepatic Cells

In particular, Phe286 6.58 and Phe290 6.62 , located at the entrance of the ligand-binding pocket, are thought to contribute to the accessibility of the acyl-modified peptide through their hydrophobic properties (You et al., 2023)