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The ASCO GI 2026 data suggest that GLP-1 therapy may be particularly relevant for metabolically high-risk populations, including individuals with obesity, insulin resistance, or type 2 diabetesgroups that now account for a substantial proportion of colorectal cancer burden

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Previous research had demonstrated that Rheb (the positive regulatory target of mTORC1) deficient CD4 + T cells suppressed the differentiation of Th1 cells by reducing the response to IL-12 and preventing T-bet transcription (37, 38)