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The systematic review did not show significant increases in Fournier gangrene or amputation despite early reports

Cell culture studies demonstrate increased expression of synaptic proteins including PSD-95, synaptophysin, and synapsin following Dihexa treatment, confirming molecular mechanisms underlying the observed synaptogenic effects

Conversely, semaglutide-focused studies in older adults have accelerated in recent years and appear to be highly promising [59,60,61]

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