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Interestingly, the size of the molecule affects its behavior: Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair

In conclusion, metabolic reliance on glutamine arises via the intrinsic functional diversity of glutamine, supporting macromolecule biosynthesis and reinforcing the TCA cycle

This is still being studied, but the clinical experience to date is consistent with this hypothesis

and (ii) induces a quantitative rise of Nrf2 and glutathione that could only be achieved by the highest non-toxic concentrations of the potent experimental Nrf2-activator DEM