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Research indicates that genetic variation in GLP-1 receptor (GLP1R), glucose-dependent insulinotropic polypeptide receptor (GIPR), and metabolic genes like FTO and MC4R may influence individual response to GLP-1 agents, though clinical application is still evolving

The most serious side effects of Rybelsus can include: Kidney Disease Pancreatitis Gallstones Hypoglycemia Yet, they are not likely to have long-term side effects as they are all treatable