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Despite their notable absence in CM, alterations in the SF3B1 gene are not unique to MM - similar mutations have also been detected in uveal melanoma, breast cancer, myelodysplastic syndromes, and chronic lymphocytic leukemia, including mutation hotspots such as codon 700, 622, 625, 662, and 666 (99, 113)

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Nerve entrapment syndromes, such as carpal tunnel syndrome or meralgia paresthetica, can lead to localized pain or discomfort that may be confused with hernia symptoms

Consult a healthcare professional if pregnant, nursing, or taking medications