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Role of dipeptidyl peptidase-4 inhibitors in new-onset diabetes after transplantation

these are crucial to progression to MASH ( The interplay between MASLD, insulin resistance, and metabolic syndrome MASLD is strongly associated with metabolic syndrome, which includes obesity, T2DM, dyslipidemia, and hypertension (Figure 2) ( Figure 2 Obesity is widely recognized as a key factor in promoting systemic inflammation, which is closely linked to the development of IR (Figure 2) ( IR is considered a central mechanism in the development and progression of MASLD to MASH and cirrhosis, impairing the liver's ability to manage fat (Figure 2) ( As MASLD progresses, hepatic inflammation, particularly involving M1 macrophages (Kupffer cells), becomes a key factor in disease progression (Table 1)

doi: 10.1002/smsc.202400280, 23

Canada offers several effective alternativesboth medications and lifestyle-based strategiesthat can support weight management and type 2 diabetes care