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GLP-1 drugs like Ozempic and Wegovy have revolutionized the management of diabetes and obesity
[PubMed: 40005999] Intra-articular Injection for Knee Pain (2021): A retrospective clinical study examined 16 patients who received intra-articular BPC-157 injections for knee pain
Importantly, supplementation can **increase** measurable NAD+ metabolism: in a 2018 randomized, placebo-controlled crossover trial published in Nature Communications by Martens and colleagues at the University of Colorado Boulder (24 healthy middle-aged and older adults), 1,000 mg/day of the NAD+ precursor nicotinamide riboside (500 mg, twice daily) elevated NAD+ in blood cells by roughly 60% versus placebo over 6 weeks, with no serious adverse events reported
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