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This protective role contributes to strengthening our immune system

Purified MDH (~1 mL) was dialyzed for 4 h in 1 L buffer 2 (20 mM MOPS-KOH pH 7.5, 150 mM NaCl) containing 10 mM EDTA followed by three times dialysis against 1 L of buffer 2

It helps ensure that therapeutic doses reach systemic circulation without the variability introduced by digestion

Other common symptoms of B12 deficiency include: Lethargy or a total lack of energy Extreme fatigue Palpitations Pale skin Feeling faint Breathlessness Weight loss and loss of appetite Your doctor may prescribe B12 injections in extreme cases that take effect right away