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GLP-1 EFFECT ON AMPK, NAMPT, AND SIRT SIGNALING The liver has a vast range functions in the body, including immunity against infection, synthesis of proteins and cholesterol, detoxification, glycogen storage, excretion of bile for fat digestion, and regulation of metabolism
However, a database analysis of nearly 200,000 individuals treated with GLP-1RAs for diabetes, obesity or both identified a discontinuation rate of 36.5% at 12 months (30)