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The parent compound, Nle-AngIV, demonstrated an exceedingly short half-life of less than 2 minutes
10.1016/j.gendis.2022.02.007 10 AntunesM.BialaG
108 The proposed mechanism for its metabolism is the cleavage of the active side chain of MEP by blood esterase(s)
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Introduction Although bone mineral density (BMD) is normal or even elevated in individuals with type 2 diabetes mellitus (T2D), T2D has been associated with an increased fracture risk ( Glucagon-like peptide-1 receptor agonists (GLP-1 RA) and dipeptidyl peptidase 4 inhibitors (DPP-4i) were both introduced in Denmark in 2007, and new drugs in the classes are continually being introduced ( Knowledge about the impact of GLP-1 RAs on bone health and fracture risk is limited
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