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The Study 333,687 veterans with type 2 diabetes starting either a GLP-1 receptor agonist (n=132,551) or a sulfonylurea (n=201,136) between 2017 and 2023

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Furthermore, SIRT3 directly deacetylates and activates carnitine palmitoyltransferase 2 (CPT2), an obligate step in mitochondrial long-chain FAO, to enhance the LC turnover pool in adipocytes, which in turn promoted lipid metabolism and anti-inflammatory polarization in macrophages