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The primary mode of action of troriluzole is reducing synaptic levels of glutamate

exenatide and lixisenatide, are based on a protein derived from saliva of the Gila monster, and only share roughly 50% of the homology of GLP-1, which could trigger immunogenicity

Am J Gastroenterology

In particular, they target areas that are important for homeostatic feeding, such as the hypothalamus, and for hedonic responses, such as the nucleus accumbens (NAc), ventral tegmental area (VTA), and laterodorsal tegmental area (LDTg) ( PPG gene is also expressed in the olfactory bulb (Merchenthaler et al., 1999), amygdala, striatum, and hippocampus (Vallof et al., 2019a)