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In addition to their role in promoting breast cancer cell proliferation [67] and mediating inflammation [68], breast CAFs deposit collagen type I and fibronectin [58], secrete matrix metalloproteinases (MMPs) [69], and promote collagen crosslinking (e.g., via lysyl oxidase (LOX)) [70]

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The mammary tumor model was created by inoculating 5 10 4 4T1 cells into the mammary adipose tissue of 68 weeks old female Balb/c mice in physiological saline solution, and it was considered as day 0

Many people experience no symptoms, while others develop knee pain, swelling, clicking, popping, or episodes of catching and locking