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It was never going to be an anti-obesity drug. In mouse studies, AOD-9604 was shown to break down fat and prevent weight gain, but it was also shown that this effect over the longer term was dependent on a specific receptor When you give AOD-9604 to mice that are deficient in this receptor the weight-losing effect is lost. Its not surprising that AOD-9604 doesnt work in humans because the receptor on which it appears to be dependent is not the same in mice and humans. For anybody who knows anything about peptides used for fat-burning, the problem should have been obvious from the get-go

The somatostatin-producing delta cells comprise ~5% of the islet cells [1]

They are generally short-lived and can be controlled with a gradual increase in dose

This is why so many women in their 40s and early 50s report that their hayfever has suddenly got worse, they've developed new food sensitivities, wine gives them a headache when it never used to, or their skin flushes and itches for no obvious reason