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In the l-carnitine group, the NIRS data at 8 weeks treatment was significantly improved as compared to the baseline (0.096 0.058 vs

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In a rat model of DOX-induced cardiotoxicity, it has been unequivocally demonstrated that DOX induces the production of ROS and transforming growth factor-beta (TGF-), thereby promoting the transformation of cardiac fibroblasts into myofibroblasts (Cappetta et al., 2016)