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Unfortunately, stress can rapidly increase free radical production and oxidative stress, and chronic stress increases the risk of other physical and mental health problems

Mechanistically, the consistent threads are collagen up-regulation, angiogenesis support, and modulation of nitric-oxide pathways all of which are biologically plausible drivers of the observed soft-tissue effects

Motor : muscle weakness, ataxia, reduced reflexes (if peripheral neuropathy) or increased reflexes and/or upgoing plantars (if central neuropathy)

This stability has made it valuable for studying gastrointestinal function, connective tissue biology, and regenerative processes