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Nonetheless, bipolar cell responses were affected as noted by increased I K but decreased I Ca amplitudes, increased ERG b-wave amplitudes, and reduced, but faster, ERG d-wave responses

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The diabetes arm REDEFINE 2, run in adults with type 2 diabetes, showed 13.7% weight loss against 3.4% on placebo at 68 weeks a smaller effect, consistent with the pattern that people with diabetes tend to lose somewhat less on these drugs