At this starting dose, appetite suppression may be minimal or absent
In the normal renal function group, one participant had a clinically significant vital sign abnormality (increased blood pressure) and one had a clinically significant ECG abnormality, with both reported as resolved mild TEAEs
doi: 10.1002/jcp.25598 139 ZhouYMaXYHanJYYangMLvCShaoYet al
Exclusion criteria were central or nephrogenic diabetes insipidus (excluded by water deprivation test or hypertonic saline test), secondary polyuria (e.g., diabetes mellitus, hypokalemia, hypercalcemia), inability to follow the study procedures, e.g., because of an unstable psychiatric condition, a history of pancreatitis, or treatment with a GLP-1 RA within the previous 3 months