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101 In addition, hypoxia-induced lactylation of serine hydroxymethyltransferase 2 (SHMT2) upregulates its protein level, enhancing methylenetetrahydrofolate dehydrogenase 1-like (MTHFD1L) expression and the stemness of esophageal squamous cell carcinoma cell lines, thus accelerating the malignant progression of esophageal cancer

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