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Funding This paper was supported by San Matteo Hospital Foundation, Internal Medicine research fundings, PRIN2017. Publishers note All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

In humans, a randomized controlled clinical trial evaluated the effect of CoQ10 administration (300 mg/day, P.O for 12 weeks) on the antioxidant system in patients with coronary artery diseases

This NFBmediated inflammation further propagates ROS generation and neuronal damage, creating a selfamplifying pathological loop that significantly exacerbates neuroinflammatory processes in neurodegenerative diseases [151]