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Indeed, hormone influence over BDNF expression has been demonstrated in gonadectomized female and male rats, showing decreased BDNF mRNA levels in the hippocampus that can be rescued after estradiol supplementation (Singh et al., 1995

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The efficacy of other GLP-1RAs, including semaglutide and dual GLP-1/GIP agonist tirzepatide, in OA treatment is still under investigation