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Published clinical evidence includes a Phase 1b multiple-ascending-dose trial reported by Enebo and colleagues (Lancet, 2021) and a Phase 2 trial in type 2 diabetes reported by Frias and colleagues (Lancet, 2023), both studying cagrilintide together with semaglutide

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Differentiation to HLCs was a 3-stage process consisting of differentiation to definitive endoderm (DEPhase I), hepatic specification to hepatoblasts/hepatic endoderm (HEPhase II), and finally maturation to hepatocyte-like cells (HLCsPhase III)

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