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Semaglutide vs Tirzepatide: Side-by-Side Comparison The table below summarises the key parameters and trial data for a quick Semaglutide vs Tirzepatide reference

Tirzepatide follows the standard escalation schedule: 2.5 mg weekly for four weeks, increasing to 5 mg, then 7.5 mg, and up to 15 mg weekly depending on weight loss response and gastrointestinal tolerance

Tirzepatide is self-administered as a subcutaneous (under the skin) injection using a single-dose pen, KwikPen, or vial with syringe, and should always be used together with diet and exercise

Both are GLP-1 medications and have similar common side effects and safety profiles