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However, various limitations of these two biomarkers, including low sensitivity and specificity, delayed rise in plasma because of functional reserve, and extrarenal clearance, demand for novel renal biomarkers to early detect and monitor drug-induced nephrotoxicity with high specificity and sensitivity

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The sublingual epithelium simply cannot accommodate the passage of larger molecules through either paracellular or transcellular routes without assistance from permeation enhancers

Then approximately 2-3 mm thick stripes were cut that included gingivomucosal tissue around the first molar, as well as gingiva both on the lingual and on the buccal side until the middle line of the second molar