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Some providers prescribe metformin as a bridge during GLP-1 discontinuation, particularly for people with insulin resistance or prediabetes

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Published by Cambridge University Press on behalf of the European Psychiatric Association Introduction Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are a class of medications that mimic the action of the natural hormone GLP-1, which plays a crucial role in regulating glucose metabolism and various other physiological processes [Reference Drucker1, Reference Trujillo, Nuffer and Smith2]

Discov Med 2 , 212 (2025)