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Semaglutide Semaglutide (Ozempic, Wegowy) is another GLP-1 receptor agonist that has a similar mechanism of action as liraglutide, and the FDA also approves it for the same indications

GLP-1Rs are expressed primarily on GABAergic cells in the VTA Next, we showed that a behaviorally relevant dose of exendin-4 that reduced cocaine seeking 8,18 crossed the blood brain barrier, bound putative GLP-1Rs on neurons in the VTA, and induced c-Fos expression in these neurons (Suppl