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Amino acid concentrations were quantified using Skyline software (MacCoss Lab Software), where MRM transitions (ion pairs) were automatically identified and integrated with manual verification as required

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Rigid body refinement of reduced OsDHAR was performed using the REFMAC5 program by placing the best molecular replacement solution

excess GPx1 decreased growth factor stimulated cellular proliferation, and reduced growth factor mediated signal transduction and activation of Akt [16]