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Importantly, we have confirmed therapeutically relevant drug accumulation in the posterior segment in both rabbits and pigs with as few as five days of once daily dosing [20, 21]

In contrast, SGLT2 inhibitors may be better suited for those with fluid overload or kidney concerns

Despite extensive research, disease-modifying therapies remain elusive, hindered by late diagnosis, limited availability of specific biomarkers, and the persistent dominance of reductionist, single-target strategies