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Combination pharmacotherapy, which involves not only gut hormones but also other molecules, appears to be a viable treatment option for metabolic syndrome

Hypothelamic-Pituitary-Adrenal Axis Tumors of the cortisol-secreting cells of the adrenal cortex secrete excessive cortisol, resulting in excessive tissue protein degradation and muscle wasting Cushing's syndrome As a source of energy, amino acid carbon skeletons are directly oxidized, or, in the starved state, converted to glucose and ketone bodies, and then oxidized

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N Engl J Med 2013