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The research team of Frias et al designed a 32-week, randomized, double-blind, parallel-group, active control trial that included adults with a diagnosis of type 2 diabetes and a body mass index of 27 and HbA1C levels ranging from 7.5% to 10% despite a daily dose of metformin

Mounjaro delivered superior and consistent A1C reductions against all of the comparators throughout the SURPASS program, which was designed to assess Mounjaro's efficacy and safety in a broad range of adults with type 2 diabetes who could be treated in clinical practice, Juan Pablo Fras, MD, medical director of the National Research Institute and a researcher involved in the SURPASS program, said in a statement

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Figure 4: Comparative responses to IV administration of GHRH or GHRP in adolescent and adult subjects